Short Answer
Yes. Rh-negative blood can usually be safely transfused to Rh-positive patients when it is otherwise ABO compatible.
Detailed Explanation
Rh-negative red blood cells do not contain the Rh(D) antigen.
Because Rh-positive patients already have the Rh antigen, receiving Rh-negative blood generally does not cause an immune reaction related to the Rh factor.
This is one reason Rh-negative blood is highly valuable, especially during emergencies.
Even so, hospitals still perform full compatibility testing before every transfusion.
Key Points
- Rh-negative blood can generally be given to Rh-positive patients.
- ABO compatibility must also be ensured.
- Cross-matching is still performed before transfusion.
- Rh-negative donations are particularly valuable in emergency medicine.
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